Faculty

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Jarod A. Zepp, PhD

Assistant Professor of Pediatrics (Pulmonary Medicine)

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Department: Pediatrics

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1f Graduate Group Affiliations 8

Cell and Molecular Biology

46 Contact information
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Children's Hospital of Philadelphia
20 Abramson Research Center
1c Office:416D Lab:414I
39 3615 Civic Center Blvd
Philadelphia, PA 19104

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13 Education:
21 9 B.S. 14 (Biology) c
36 University of Colorado Denver, 2007.
21 a Ph.D. 1f (Molecular Medicine) c
38 Case Western Reserve University, 2014.
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Links
4c Lab Website
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b6 > Perelman School of Medicine > Faculty > Details a

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Selected Publications

75 Zepp JA*, Morley MP, Loebel C, Kremp MM, Chaudhry FN, Basil MC, Leach JP, 4d Liberti DC, Niethamer TK, Ying Y, Jayachandran S, Babu A, Zhou S, Frank DB, d9 Burdick JA, Morrisey EE*: Genomic, epigenomic and biophysical cues controlling the emergence of the lung alveolus. Science 371(6534): eabc3172, Mar 2021 Notes: *co-corresponding authors.

120 Niethamer TK, Stabler CT, Leach JP, Zepp JA, Morley MP, Babu A, Zhou S, Morrisey EE.: Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury. Elife 9(2): e53072, Feb 2020.

138 Liberti DC*, Zepp JA*, Bartoni CA, Liberti KH, Zhou S, Liu M, Morley MP, Morrisey EE: "Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate" Dev Biol 454(2): 108-117, Oct 2019.

e5 Zepp JA and Morrisey EE.: "Cellular crosstalk in the development and regeneration of the respiratory system" Nat Rev Mol Cell Biol 20(9): 551-566, Sep 2019.

17a Frank DB, Penkala IJ, Zepp JA, Sivakumar A, Linares-Saldana R, Zacharias WJ, Stolz KG, Pankin J, Lu M,Wang Q, Babu A, Li L, Zhou S, Morley MP, Jain R, Morrisey EE.: "Early lineage specification defines alveolar epithelial ontogeny in the murine lung" Proc Natl Acad Sci U S A 116(10): 4362-4371, Mar 2019.

125 Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkhaleel F, Kong J, Zhou S, Cantu E, Morrisey EE: "Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor" Nature 555(7695): 251-255, Mar 2018.

11c Zepp JA, Frank DB, Zacharias WJ, Cavanaugh C, Morley MM, Morrisey EE: "Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung" Cell 170(6): 1134- 1148, Sep 2017.

16b Frank DB, Peng T, Zepp JA, Snitow M, Vincent T, Penkala IJ, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE: "Emergence of a wave of Wnt signaling that regulates lung alveologenesis through controlling epithelial self-renewal and differentiation" Cell Reports 17(9): 2312-2325, Nov 2016.

fb Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise 70 AG, Dubyak GR, Ransohoff RM, Li X: "T cell-intrinsic ASC critically promotes TH17-mediated experimental 5a autoimmune encephalomyelitis" Nat Immunol 17(5): 583-92, May 2016.

186 Wu L, Chen X, Zhao J, Martin B, Zepp JA, Ko JS, Gu C, Cai G, Ouyang W, Sen G, Stark GR, Su B, Vines CM, Tournier C, Hamilton TA, Vidimos A, Gastman B, Liu C, Li X: "A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis" J Exp Med 212(10): 1571- 87, Sep 2015.

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