Faculty

Xiao Wang, PhD

Research Assistant Professor of Medicine (Cardiovascular Medicine)

Department: Medicine

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

11-189 Smilow Translational Research Bldg.
3400 Civic Center Blvd
Philadelphia, PA 19104

Lab: 215-898-9011

Email:
xiao8@pennmedicine.upenn.edu

Education:
BS (Bioscience)
College of Life Science, Zhejiang University, 2007.
PhD (Molecular Biology and Biochemistry)
Institute for Nutritional Sciences, Chinese Academy of Sciences, 2013.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Choe D, Burke M, Brandimarto JA, Marti-Pamies I, Yob J, Yang Y, Morley MP, Drivas TG, Day S, Levin M, Damrauer S, Wang X*, Cappola TP*.: Sex-Specific Effects of MTSS1 Downregulation on Dilated Cardiomyopathy. Circulation 150: 1648-1651, Nov 2024 Notes: (*These authors jointly directed this work).

Brooks DL, Whittaker MN, Said H, Dwivedi G, Qu P, Musunuru K, Ahrens-Nicklas RC, Alameh MG, Wang X.: A base editing strategy using mRNA-LNPs for in vivo correction of the most frequent phenylketonuria variant. HGG Adv 5: 100253, Jan 2024.

Brooks DL, Whittaker MN, Qu P, Musunuru K, Ahrens-Nicklas RC, Wang X.: Efficient in vivo prime editing corrects the most frequent phenylketonuria variant, associated with high unmet medical need. Am J Hum Genet 110: 2003-2014, Dec 2023.

Whittaker MN, Testa LC, Quigley A, Jindal I, Cortez-Alvarado SV, Qu P, Yang Y, Alameh MG, Musunuru K, Wang X.: Epigenome Editing Durability Varies Widely Across Cardiovascular Disease Target Genes. Arterioscler Thromb Vasc Biol Oct 2023.

Brooks DL, Carrasco MJ, Qu P, Peranteau WH, Ahrens-Nicklas RC, Musunuru K, Alameh MG, Wang X.: Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing. Nat Commun 14: 3451, Jun 2023.

Davis JR, Wang X, Witte IP, Huang TP, Levy JM, Raguram A, Banskota S, Seidah NG, Musunuru K, Liu DR.: Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors. Nat Biomed Eng 6(11): 1272-1283, Nov 2022.

Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR: Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell 185(2): 250-265, Jan 2022.

Morley MP*, Wang X*, Hu R, Brandimarto J, Tucker NR, Felix JF, Smith NL, Harst P, Ellinor PT, Margulies KB, Musunuru K, Cappola TP: Cardioprotective Effects of MTSS1 Enhancer Variants. Circulation 139(17): 2073–2076, Apr 2019 Notes: (*These authors contributed equally to this work).

Wang X, Musunuru K: Confirmation of causal rs9349379-PHACTR1 expression quantitative trait locus in human-induced pluripotent stem cell endothelial cells. Circ Genom Precis Med 11(10): e002327, Oct 2018.

Small KS*, Todorčević M*, Civelek M*, El-Sayed Moustafa JS*, Wang X*, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris A, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox R, Karpe F, McCarthy MI: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. Nat Genet 50(4): 572-580, Apr 2018 Notes: (*These authors contributed equally to this work).