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  • Krithika Lingappan
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Faculty

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Krithika Lingappan, MBBS, PhD, MS

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Associate Professor of Pediatrics (Neonatology & Newborn Services)
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Department: Pediatrics
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1f Graduate Group Affiliations 8 a
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Children's Hospital of Philadelphia
1f Division of Neonatology
3e 3401 Civic Center Boulevard
Philadelphia, PA 19014
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Email: krithika.lingappan@pennmedicine.upenn.edu
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13 Education:
21 9 MBBS 15 (Medicine) c
4f Kilpauk Medical College, MGR Medical University, India, 2002.
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33 Baylor College of Medicine, 2012.
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5a Baylor College of Medicine Graduate School of Biomedical Sciences, 2018.
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Links
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Description of Clinical Expertise

2b5 I take particular interest in evidence-based medicine (EBM) and have led several EBM initiatives. We are also interested in translational research projects related to long-term outcomes (pulmonary and cardiovascular) after preterm birth. I have leadership experience at national and regional organizations. As the leader of several national-level groups, I have created a unique niche for herself as a leader in the neonatology subspecialty with my involvement in the American Academy of Pediatrics (AAP), Section of neonatal-perinatal medicine (SONPM), NIH-funded lung basic-science research, evidence-based clinical neonatology practice, and trainee engagement and education.
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Description of Research Expertise

2b5 My research focuses on reducing long-term morbidities such as chronic lung disease (bronchopulmonary dysplasia) in premature babies. Specifically, our research focuses on elucidating the mechanisms behind sex-specific differences in the incidence of BPD. In the future, this research should lead to therapeutic lung-protective strategies. There is a great need for such therapeutic strategies to improve outcomes in premature babies, given that the incidence of BPD in premature neonates has been reported to be as high as 50%. The long-term goal of this research is to develop new translational strategies, both therapeutic and diagnostic in the field of neonatal lung injury.
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Selected Publications

2c1 Rojas-Quintero J, Faner R, Chiu CY, Kue JT, Zhang Y, Sanz Rubio D, Colborg AS, Jakwerth CA, Schmidt-Weber CB, Maitland-van der Zee AH, Abdel-Aziz MI, Pilon AL, Owen CA, Plosa EJ, Kinney GL, Mc-Grath Morrow S, Gazzaneo MG, Cortes Santiago N, Lingappan K, Ledford J, Spence J, Sucre JM, Sauler M, Wu TD, Agusti A, Wheelock A, Illi S, von Mutius E, Bowler RP, Celli B, Abman SH, Wells JM, Polverino F; ALLIANCE study group, ECLIPSE and COPDGene investigators.: Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan. Am J Respir Crit Care Med Page: doi: 10.1164, Oct 2025 Notes: epub ahead of print.

 164 Fensterheim BA, McKeague M, Mathew D, Shwetank, Pattekar A, Nasta S, Kee M, Clendenin C, Martinez Z, Diorio C, Greenplate AR, Lingappan K, Wherry EJ.: Perturbation of the Preterm Human Immune System in Early Life. medRxiv Page: doi: 10.1101/2025.09.03.25334934, Sep 2025 Notes: epub.

 124 Horowitz EN, Good M, Machut KZ, Ahmad K, Wright CJ, Lingappan K.: NIH-funded neonatologist physician-scientists: an exploration of equity and success. Pediatr Res Page: doi: 10.1038, Sep 2025 Notes: epub ahead of print.

 d1 Lingappan K.: Biological sex and transfusion practices in the NICU. Pediatr Res Page: doi: 10.1038, Sep 2025 Notes: epub ahead of print.

 152 Sonti S, Cantu A, Guttierez MC, Leek C, Pelton P, Jensen EA, Lingappan K.: Patient-derived airway organoids from BAL fluid model injury and therapy responses in neonatal bronchopulmonary dysplasia. bioRxiv Page: doi: 10.1101/2025.08.11.669535, Aug 2025 Notes: epub.

 1c4 Lingappan K, Sundar IK, Prakash YS, Redente EF, Sin DD, Han MK, Lahm T, Krymskaya VP, Kotton DN, Kulkarni HS, Jain R, Königshoff M, Eghbali M, Anguera M, Arnold A, Silveyra P, DeMeo DL.: Addressing Sex as a Biological Variable in Preclinical Models of Lung Disease: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med 211(8): 1346-1368, Aug 2025.

 133 Lee A, Weitkamp JH, Tune A, Couto J, Lingappan K.: Success and opportunities of the American Academy of Pediatrics Marshall Klaus research grant program in neonatal-perinatal medicine. Journal of Perinatology 45(5): 595-599, May 2025.

 d4 Lingappan K, Matthay MA: Unlocking the Therapeutic Code of Mesenchymal Stromal Cells. Am J Respir Crit Care Med. 211(3): 313-315, Mar 2025.

 112 Wiener S, Zhang H, Lingappan K, Callaway D.: Acquired Lobar Emphysema in Severe BPD: Who, Why, and What can we do about it? Poster Presentation, Pediatric Academic Societies Meeting, Honolulu, HI 2025.

 129 K. Lingappan, S. Han, D. Taha, K. Nilan, and K. Gibbs.: The Lymphatic Dysfunction Phenotype in Infants With Severe Bronchopulmonary Dysplasia (BPD): A Distinct, Rare Endophenotype. Am J Respir Crit Care Med 211: A1263, 2025.

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