Faculty

Foteini Mourkioti, PhD

Associate Professor of Orthopaedic Surgery

Department: Orthopaedic Surgery

Graduate Group Affiliations

Contact information

McKay Orthopaedic Research Laboratory
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081

Office: 215-898-8214
Fax: 215-573-2133
Lab: 215-573-3645

Email:
fmour@pennmedicine.upenn.edu

Publications

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Education:
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.

Links
Search PubMed for articles
Penn Cardiovascular Institute
Mourkioti Lab
Penn Institute of Regenerative Medicine
McKay Orthopaedic Research Laboratory
Penn Center for Musculoskeletal Disorders
The Pennsylvania Muscle Institute

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Keywords: muscle stem cells, stem cell activation, muscle disorders, mechanobiology, aging, telomeres, NF-kB signaling, muscle regeneration, stem cell regulation, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.

Selected Publications

He Q, Lu J, Liang Q, Yao L, Sun T, Wang H, Duffy M, Jiang X, Lin Y, Lee JH, Ahn J, Dyment NA, Mourkioti F, Boerckel JD, Qin L. : Prg4+ fibroadipogenic progenitors in muscle are crucial for bone fracture repair. Proc Natl Acad Sci U S A 5(122): 31, Aug 2025.

Chakkalakai SA, Grossman NZ, Mejias Rivera L, Roberts DW, Pacifici M, Mourkioti F, Shore EM.: An Inducible Knock-In Mouse Model of Fibrodysplasia Ossificans Progressiva (FOP) Shows Spontaneous Formation of Heterotopic Ossification. JBMR Plus July 2025.

Hilman MC, Mourkioti F, Das S, Cullen DK.: Tensile Forces and Nanofiber Alignment Influence Both Innervated and Non-Innervated Skeletal Myofiber Formation in Custom Mechanobioreactors. Biotechnology J. 20(6), Jun 2025.

Park G, Grey JA, Mourkioti F, Han WM.: 3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function. Advanced Biology 9(4), April 2025 Notes: This paper was chosen for the Cover Page of the journal for the month of April: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adbi.202570098.

Ma N., Mourkioti F: Ex vivo two-photon imaging of whole-mount skeletal muscles to visualize stem cell behavior. STAR Protocols 5(1): 1-14, March 2024.

Das S, Hilman MC, Yang F, Mourkioti F, Yang W, Cullen DK.: Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes. Skeletal Muscle 7(14), March 2024.

Tichy ED, Lee JH, Li G, Estep KN, Johnson FB, Mourkioti F.: Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length. NPJ Microgravity 15(9): 76, September 2023 Notes: DOI : 10.1038/s41526-023-00303-1.

Bautista C.A., Srikumar A., Tichy E.D., Qian G., Jiang X., Qin L., Mourkioti F., Dyment N. CD206: CD206+ tendon resident macrophages and potential crosstalk with fibroblasts and the ECM during tendon growth and maturation. Front. Physiol., Sec. Skeletal Physiology 14, February 2023.

Ma N., Chen D., Lee, J.H., Kuri P., Hernandez E.B., Kocan B., Mahmood H., Tichy E.D., Rompolas P., Mourkioti F.: Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states. Science Advances. Science, 8(11): 1-14, March 2022.

Stanley A, Tichy ED, Kocan J, Roberts DW, Shore EM and Mourkioti F.: Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva NPJ Regenerative Medicine-Nature 7(1), January 2022 Notes: doi: 10.1038/s41536-021-00201-8.